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A disease in which cancer cells form in the tissues of the penis.

Human papillomavirus (HPV) infection may increase the risk of penile cancer. Condom use and the HPV vaccine can help prevent infection with HPV.

Penile cancer may begin as a blister on the foreskin, head or shaft of the penis. It may become a wart-like growth that discharges blood or foul-smelling liquid.

Surgery is the most common treatment for all stages of penile cancer. Other options include radiation and chemotherapy. Lymphnodes in the groin and the pelvis may also need removal, depending on the grade and stage of the disease.

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